电邮这篇文章 Nefopam as a component of multimodal postoperative analgesia: the result in the group of patients undergone surgery for head and neck tumors in context of multicenter trial
- 作者: Balandin V.1, Gorobets E.1
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隶属关系:
- FSBI “N.N. Blokhin Russian Cancer Research Center” RAMS
- 期: 卷 9, 编号 2 (2015)
- 页面: 5-8
- 栏目: Articles
- URL: https://journals.rcsi.science/1993-6508/article/view/36232
- DOI: https://doi.org/10.17816/ра.v9i2.36232
- ID: 36232
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The goal of the study was to evaluate the affectivity of nefopam in postoperative pain management. Two hundred patients were enrolled into the prospective multicenter study on the base of 8 leading research centers of Russian Federation. The cohort includes 25 adult patients undergone surgery for head and neck tumors from Blokhin Russian Oncologic Research Center. All patient received analgesia for 3 postoperative days along the following scheme: nefopam 20mg i.v. 30 min before the end of the surgery, then every 8 hours combination of nefopam and NSAID. Visual- analogical 10-ball scale was used to evaluate analgesia. The results of the study suppose effectiveness and safety of nefopam as a component of postoperative multimodal analgesia.
作者简介
V. Balandin
FSBI “N.N. Blokhin Russian Cancer Research Center” RAMS115478, Moscow
Evgeniy Gorobets
FSBI “N.N. Blokhin Russian Cancer Research Center” RAMS
Email: egorobets@mail.ru
115478, Moscow
参考
- Dolin S., Cashman J., Blad S. Effectiveness of acute postoperative pain management: I. Evidence from published data. Br. J. Anaesth. 2002; 89: 409-423.
- Овечкин А.М., Свиридов С.В. Послеоперационная боль и обезболивание: современное состояние проблемы. Медицина критических состояний. 2011; 6(37): 20-31.
- Strom B., Berlin J., Kinman J. Parenteral ketorolac and risk of gastrointestinal and operative site bleeding. JAMA. 1996; 275: 376-382.
- Huang N., Cunningham F., Laurito C. E. et al. Can we do better with postoperative pain management? Am J Surg. 2001 Nov; 182(5): 440-448.
- Kehlet H., Dahl J.B. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth. Analg. 1993; 77:1048-1056.
- Kehlet H. Labat Lecture 2005. Surgical stress and postoperative outcome - from here to where? Reg. Anesth. Pain Med. 2006; 31: 47-52.
- Fernandez-Sanchez М., Diaz-Trelles R., Groppetti A. Nefopam, an analogue of or-phenadrine, protects against both NMDA receptor-dependent and independent vera-tridine-induced neurotoxicity. Amino Acids. 2002; 23: 31-36.
- Verleye M., Andre N., Heulard I., Gillardin J. Nefopam blocks voltagesensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004; 1013: 249-255.
- Kapfer et al. Nefopam and ketamine comparably enhance postoperative analgesia. Anesth. Analg. 2005; 100: 169-174.
- Tirault et al. The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery. Anesth. Analg. 2006; 102: 110-117.
- Bilotta F., Pietropaoli P., Sanita R. Nefopam and tramadol for the prevention of shivering during neuroaxial anesthesia. Reg. Anesth.Pain.Med. 2002; 27: 380-384
- Piper S., Suttner S., Schmidt S. Nefopam and clonidine in the prevention of postanesthetic shivering. Anaesthesia. 1999; 54: 695-699.
- Piper S., Rohm K., Suttner S. A comparison of nefopam and clonidine for the prevention of postanaesthetic shivering: a comparative, double-blind and placebo-controlled dose-ranging study. Anaesthesia. 2004; 59: 559-564.
- Delage N., Maaliki H., Beloeil H. Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients. Anesthesiology. 2005; 102: 1211-1216.
