Somatic state assessment of the health of patients with retinoblastoma in a long-term follow-up
- Authors: Saakyan S.V.1,2, Ivanova O.A.1, Revishvili S.S.1, Tsygankov A.I.1,2
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Affiliations:
- Helmholtz National Medical Research Center of Eye Diseases
- Moscow State Medical and Dental University
- Issue: Vol 16, No 4 (2021)
- Pages: 13-20
- Section: Original study article
- URL: https://journals.rcsi.science/1993-1859/article/view/83408
- DOI: https://doi.org/10.17816/rpoj83408
- ID: 83408
Cite item
Abstract
AIM: To comprehensively assess the incidence and nature of the chronic diseases in patients with retinoblastoma in the long-term follow-up
MATERIAL AND METHODS: The study analyzed the long-term treatment results of 176 patients with retinoblastoma. Group 1 included 46 patients aged <18 years and Group 2 included 88 patients aged >18 and <35 years. A gynecologist and a urologist were consulted, a medical history was taken, and a physical examination with emphasis on the presence of secondary sexual characteristics and laboratory tests were performed to assess the endocrine function in surviving patients aged <18 years. Anamnestic data were used in patients aged >18 years.
RESULTS: The somatic status data analysis of 46 surviving adolescents revealed that 29 (63%) have abnormalities. Chronic gastritis and gastroduodenitis, biliary dyskinesia, fatty hepatosis, and lactase deficiency predominate in gastrointestinal structure diseases. Respiratory diseases are represented by chronic nasopharyngeal diseases in 13.0% of children. Secondary immunodeficiency condition was diagnosed in 3 (6.5%) patients. Musculoskeletal system and connective tissue pathologies in deforming dorsopathies were identified in 10.9% of cases and bone and joint pain were identified in 8.7%. Chronic conditions were found in 42 (47.7%) of 88 patients in Group 2. Somatic disorders were found in 95.2%, hormonal disorders in 11.9%, psycho-emotional disorders in 9.5%, and combined pathology in 9.5% of cases. Endocrine pathology was detected in 14 patients (30.4%) aged <18 years.
CONCLUSION: Retinoblastoma survivors have a high risk of somatic and endocrine disorders. The main risk factors are distance radiation therapy and alkylating agents. Regular lifelong follow-up of these patients is necessary to establish a medical rehabilitation system for children with retinoblastoma.
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##article.viewOnOriginalSite##About the authors
Svetlana V. Saakyan
Helmholtz National Medical Research Center of Eye Diseases; Moscow State Medical and Dental University
Email: svsaakyan@yandex.ru
ORCID iD: 0000-0001-8591-428X
SPIN-code: 4783-9193
MD, Dr of Med. Sci, Professor
Russian Federation, 14/19, Sadovaya Chernogryazskaya Street, Moscow, 105062; MoscowOlga A. Ivanova
Helmholtz National Medical Research Center of Eye Diseases
Author for correspondence.
Email: ivola2003@list.ru
ORCID iD: 0000-0002-0089-0328
SPIN-code: 8332-3661
MD, PhD
Russian Federation, 14/19, Sadovaya Chernogryazskaya Street, Moscow, 105062Syuzanna S. Revishvili
Helmholtz National Medical Research Center of Eye Diseases
Email: syuzanna9.05@mail.ru
ORCID iD: 0000-0001-9098-5912
MD
Russian Federation, 14/19, Sadovaya Chernogryazskaya Street, Moscow, 105062Alexander I. Tsygankov
Helmholtz National Medical Research Center of Eye Diseases; Moscow State Medical and Dental University
Email: alextsygankov1986@yandex.ru
ORCID iD: 0000-0001-9475-3545
SPIN-code: 6476-4740
MD, PhD, researcher at ocular oncology and radiology department
Russian Federation, 14/19, Sadovaya Chernogryazskaya Street, Moscow, 105062; MoscowReferences
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