The effect of quercetin on hepatic differentiation of human adipose-derived mesenchymal stem cells
- Autores: Pinchuk S.1, Vasilevich I.1, Kvacheva Z.1, Volotovski I.1
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Afiliações:
- Institute of Biophysics and Cell Engineering
- Edição: Volume 10, Nº 5 (2016)
- Páginas: 357-364
- Seção: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212159
- DOI: https://doi.org/10.1134/S1990519X16050102
- ID: 212159
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Resumo
Human adipose-derived mesenchymal stem cells (MSCs) can be stimulated to differentiate into hepatic cells. MSC differentiation was induced by fibroblast growth factor-4, hepatocyte growth factor, oncostatin M, and dexamethasone. The influence of quercetin on MSC hepatic differentiation in culture was assayed, and 1 or 10 μmole/L quercetin added into the induction medium enhanced the manifestation of MSC hepatic differentiation. Urea secretion, cytokeratin 19 expression, and α-fetoprotein synthesis were increased. Quercetin modulated CYP1A–cytochrome P450 activity in the differentiated cells. MSCs differentiated in the presence of quercetin exhibited higher viability and resistance to oxidative stress.
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Sobre autores
S. Pinchuk
Institute of Biophysics and Cell Engineering
Autor responsável pela correspondência
Email: pinchuksv@mail.ru
Belarus, Minsk, 220072
I. Vasilevich
Institute of Biophysics and Cell Engineering
Email: pinchuksv@mail.ru
Belarus, Minsk, 220072
Z. Kvacheva
Institute of Biophysics and Cell Engineering
Email: pinchuksv@mail.ru
Belarus, Minsk, 220072
I. Volotovski
Institute of Biophysics and Cell Engineering
Email: pinchuksv@mail.ru
Belarus, Minsk, 220072