Can any breast skin thickening be staged as T4?

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Data analysis showed that many diagnostic issues in breast cancer patients with skin involvement are not systematized. In some cases when the tumor is small and skin involvement symptoms are minimal ("local" skin edema), should this category of patients be considered as patients with non-inflammatory skin involvement breast cancer? Current research confirms the presence of skin involvement has much less prognostic value than, for example, tumor size or lymph node metastases, and the surgical term "unresectable" may not always be adequate. In addition, clinical data often do not correspond to pathological data, which also complicates the staging and leads to "overtreatment" of such patients. Thus, further research is needed to identify categories of breast cancer (patients with skin involvement similar in prognosis, as well as to individualize approaches to local and systemic treatment.

作者简介

Viktoriia Amosova

Blokhin National Medical Research Center of Oncology

编辑信件的主要联系方式.
Email: amosova_va@mail.ru
ORCID iD: 0000-0001-7207-631X
SPIN 代码: 4726-5951

oncologist

俄罗斯联邦, Moscow

Aleksandr Petrovskii

Blokhin National Medical Research Center of Oncology; Sechenov First Moscow State Medical University (Sechenov University)

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-7514-280X
SPIN 代码: 5441-2747
Scopus 作者 ID: 36949543000

Cand. Sci. (Med.)

俄罗斯联邦, Moscow

Marina Karpova

Blokhin National Medical Research Center of Oncology

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-4945-982X

Graduate Student

俄罗斯联邦, Moscow

Nataliia Ponedel’nikova

Blokhin National Medical Research Center of Oncology

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-8047-3523

Cand. Sci. (Med.)

俄罗斯联邦, Moscow

Mona Frolova

Blokhin National Medical Research Center of Oncology

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-8149-0085
SPIN 代码: 2809-7737

Cand. Sci. (Med.)

俄罗斯联邦, Moscow

参考

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  10. Güth U, Wight E, Schötzau A, et al. A new approach in breast cancer with non-inflammatory skin involvement. Acta Oncol. 2006;45(5):576-83.
  11. Mateo AM, Mazor AM, DeMora L, et al. Patterns of Care and Efficacy of Chemotherapy and Radiotherapy in Skin-Involved Breast Cancers of All Sizes. Clin Breast Cancer. 2019;19(4):292-303.

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1. JATS XML
2. Fig. 1. Mediolateral oblique and craniocaudal Mammograms. Inflammatory breast disease (IBC). The skin thickening, diffuse infiltration of breast tissue (a) and axillary lymph node metastases (b) are determined.

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3. Fig. 2. Sonogram. The thickness of the skin and active blood flow in the skin are estimated.

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4. Fig. 3. T2 (a) and post-contrast T1 (b) magnetic resonance imaging. The thickening of the skin and high signal intensity on T2-weighted and post-contrast images are determined.

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5. Fig. 4: a – secondary IBC, local – "true" thickening of the skin over the tumor; b – significant dimpling on the skin over the tumor without edema; c – the state after core biopsy.

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