Can any breast skin thickening be staged as T4?

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Abstract

Data analysis showed that many diagnostic issues in breast cancer patients with skin involvement are not systematized. In some cases when the tumor is small and skin involvement symptoms are minimal ("local" skin edema), should this category of patients be considered as patients with non-inflammatory skin involvement breast cancer? Current research confirms the presence of skin involvement has much less prognostic value than, for example, tumor size or lymph node metastases, and the surgical term "unresectable" may not always be adequate. In addition, clinical data often do not correspond to pathological data, which also complicates the staging and leads to "overtreatment" of such patients. Thus, further research is needed to identify categories of breast cancer (patients with skin involvement similar in prognosis, as well as to individualize approaches to local and systemic treatment.

About the authors

Viktoriia A. Amosova

Blokhin National Medical Research Center of Oncology

Author for correspondence.
Email: amosova_va@mail.ru
ORCID iD: 0000-0001-7207-631X
SPIN-code: 4726-5951

oncologist

Russian Federation, Moscow

Aleksandr V. Petrovskii

Blokhin National Medical Research Center of Oncology; Sechenov First Moscow State Medical University (Sechenov University)

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-7514-280X
SPIN-code: 5441-2747
Scopus Author ID: 36949543000

Cand. Sci. (Med.)

Russian Federation, Moscow

Marina S. Karpova

Blokhin National Medical Research Center of Oncology

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-4945-982X

Graduate Student

Russian Federation, Moscow

Nataliia V. Ponedel’nikova

Blokhin National Medical Research Center of Oncology

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-8047-3523

Cand. Sci. (Med.)

Russian Federation, Moscow

Mona A. Frolova

Blokhin National Medical Research Center of Oncology

Email: amosova_va@mail.ru
ORCID iD: 0000-0002-8149-0085
SPIN-code: 2809-7737

Cand. Sci. (Med.)

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Mediolateral oblique and craniocaudal Mammograms. Inflammatory breast disease (IBC). The skin thickening, diffuse infiltration of breast tissue (a) and axillary lymph node metastases (b) are determined.

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3. Fig. 2. Sonogram. The thickness of the skin and active blood flow in the skin are estimated.

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4. Fig. 3. T2 (a) and post-contrast T1 (b) magnetic resonance imaging. The thickening of the skin and high signal intensity on T2-weighted and post-contrast images are determined.

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5. Fig. 4: a – secondary IBC, local – "true" thickening of the skin over the tumor; b – significant dimpling on the skin over the tumor without edema; c – the state after core biopsy.

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