Use of local antiviral therapy for glossitis caused by the herpes virus type IV: a clinical experience

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BACKGROUND: This article discusses approaches to the diagnosis and treatment of glossitis caused by the herpes virus type IV using a local antiviral component (Epstein–Barr virus, EBV). The results of the clinical and laboratory picture of the disease in dynamics before and after treatment (3 and 6 months) were studied. Clinically significant results were obtained, confirming the effectiveness of the proposed treatment method.

AIM: To develop a highly effective protocol for the treatment of EBV-related glossitis.

MATERIALS AND METHODS: Fifty patients aged 27–52 years diagnosed with EBV-related glossitis were examined. All patients underwent PCR diagnostics for HSV-1, HSV-2, EBV, CMV and herpes virus type 6 in saliva and EBV DNA in blood and serological examination for EBV antigens. An infectious disease specialist and local antiviral therapy, that is, appropriate gels/liniments, were included in the treatment for glossitis. Its clinical and laboratory efficacy was investigated 3 and 6 months after treatment.

RESULTS: EBV was detected in all the examined patients, at a concentration of 14000–1200000 mg/ml. HSV-2 and CMV were often detected in the participants of this study (up to 70%) at a concentration of 720–12000 mg/ml, along with a low detection rate of HSV-1 and HSV-6 in saliva (up to 7%, respectively) at a concentration of 540–820 mg/ml. The viral load of EBV in the blood was detected in 15.2% of the patients (0.6–3.4 Ig 105 copies/ml). Analysis of the ELISA results revealed Ig class G to NA, VCA, and EBNA antigens of EBV.

CONCLUSION: The use, along with a systemic, local antiviral component, is highly effective in the treatment of glossitis caused by EBV, including when EBV coexists with other types of herpes virus.

作者简介

Anastasia Serazetdinova

National Research Mordovia State University

编辑信件的主要联系方式.
Email: hosi7A@yandex.ru
ORCID iD: 0009-0003-9913-3929
SPIN 代码: 8077-9108

MD, Cand. Sci. (Medicine), Associate Professor

俄罗斯联邦, 15 Lenin avenue, Saransk 430005

Dmitry Trunin

Samara State Medical University

Email: trunin-027933@yandex.ru
ORCID iD: 0000-0002-7221-7976
SPIN 代码: 5951-4659

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Samara

Elena Yeliseikina

National Research Mordovia State University

Email: trifan.elena2994@gmail.com
ORCID iD: 0000-0002-5390-3591
SPIN 代码: 2387-3847
俄罗斯联邦, 15 Lenin avenue, Saransk 430005

Ilya Zakharkin

National Research Mordovia State University

Email: zakharkinas@mail.ru
ORCID iD: 0000-0001-7132-4887
SPIN 代码: 9437-4326
俄罗斯联邦, 15 Lenin avenue, Saransk 430005

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2. Fig. 1. Patient E., 49 years old: a — plaque, hyperplasia of the filamentous papillae of the tongue in glossitis caused by the Epstein–Barr virus; b — hyperplasia of the leaf-shaped, grooved papillae of the tongue in glossitis caused by Epstein–Barr virus.

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3. Fig. 2. The frequency of representatives of the herpes virus in saliva. ВПГ — herpes simplex virus, ВЭБ — Epstein–Barr virus, ЦМВ — cytomegalovirus.

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4. Fig. 3. Patient Е., 49 years old. Restoration of filamentous papillae 3 months after treatment.

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5. Fig. 4. Patient E., 49 years old, 6 months after treatment: a — absence of hyperplasia of the filamentous papillae of the tongue, preservation of hyperplasia of the leaf-shaped papillae of the tongue; b — minor hyperplasia of the grooved papillae of the tongue.

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