Use of orthodontic treatment protocols in patients with chronic periodontitis and arterial hypertension
- Authors: Eremin A.V.1, Lepilin A.V.1, Lipatova T.E.1
-
Affiliations:
- V.I. Razumovsky Saratov State Medical University
- Issue: Vol 25, No 3 (2021)
- Pages: 233-239
- Section: Clinical Investigation
- URL: https://journals.rcsi.science/1728-2802/article/view/70736
- DOI: https://doi.org/10.17816/1728-2802-2021-25-3-233-239
- ID: 70736
Cite item
Abstract
BACKGROUND: The wide prevalence and mutual influence of periodontitis and arterial hypertension determine the importance of choosing a rational approach to denture prosthetics in this patients.
AIM: The study was to choose a rational tactics of dental prosthetics in patients with chronic periodontitis and arterial hypertension based on a clinical and instrumental assessment of the periodontal condition and morphofunctional characteristics of neuroendocrine gum cells.
MATERIALS AND METHODS: The results of the examination of 120 patients with periodontitis and hypertension are presented, of which 90 patients had denture defects, 30 patients — intact dentition. Clinical examination, immunohistochemical, and morphometric studies were performed. 90 patients underwent prosthetics of dentition defects, of which: 32 patients were fitted with metal dentures, 30-metal-ceramic dentures, 28 patients were fitted with thermoplastic resin removable partial dentures.
RESULTS: Periodontitis in patients with hypertension is characterized by more significant changes in the expression of endothelin-1-, melatonin- and endothelial NO-synthase-like cells of gum, than periodontitis in patients without somatic pathology. After periodontal treatment, the use of metal-ceramic dentures and thermoplastic resin removable partial dentures by a year-long persistent remission of periodontitis in 85.7–86.7% of patients is accompanied. Remission is achieved against the background of satisfactory hygiene indicators and restoring the neurotransmitter balance of the oral cavity. After a year of metal dentures, 43.7% of patients report an exacerbation of periodontitis, which by poor hygiene and local neuroendocrine imbalance is facilitated.
CONCLUSION: The use of metal-ceramic dentures and thermoplastic resin removable partial dentures is the preferred option for prosthetics of dentition defects in patients with periodontitis and hypertension.
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##article.viewOnOriginalSite##About the authors
Andrey V. Eremin
V.I. Razumovsky Saratov State Medical University
Email: pr-ereminav@yandex.ru
ORCID iD: 0000-0002-0457-3303
SPIN-code: 7561-0020
ResearcherId: AAJ-6804-2021
MD, Cand. Sci. (Med.), assistant professor
Russian Federation, 112, Bolshaya Kazachya str., 410012, SaratovAleksandr V. Lepilin
V.I. Razumovsky Saratov State Medical University
Email: lepilins@mail.ru
ORCID iD: 0000-0001-6940-5178
SPIN-code: 4293-9439
Scopus Author ID: 6603785447
ResearcherId: B-5281-2017
MD, Dr. Sci. (Med.), Professor
Russian Federation, 112, Bolshaya Kazachya str., 410012, SaratovTatiana E. Lipatova
V.I. Razumovsky Saratov State Medical University
Author for correspondence.
Email: lipatova.t@inbox.ru
ORCID iD: 0000-0002-7401-9930
SPIN-code: 2483-3578
Scopus Author ID: 36892031000
ResearcherId: A-6675-2017
MD, Dr. Sci. (Med.), assistant professor
Russian Federation, 112, Bolshaya Kazachya str., 410012, SaratovReferences
- Tsimbalistov AV, Lobanovskaya AA, Mikhailova ES. Diagnostics of intolerance of structural dental materials in the clinic of orthopedic dentistry. Dental South. 2012;(2):30–32. (In Russ).
- Hannah VE, O’Donnell L, Robertson D, Ramage G. Denture Stomatitis: Causes, Cures and Prevention. Prim Dent J. 2017;6(4):46–51. doi: 10.1308/205016817822230175
- Pravdivtsev VA, Shashmurina VR, Kirillov SK, et al. Pathological processes initiated by metal-ceramic dentures. Russian journal of dentistry. 2013;3:30–34. (In Russ).
- Boitsov SA, Shalnova SA, Deev AD. Mortality from cardiovascular diseases in the Russian Federation and possible mechanisms of its change. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2018;8:98–103. (In Russ).
- Eremin AV, Lipatova TE, Lepilin AV, Eremin VI. Assessment of cardiovascular risk factors in patients with chronic periodontitis. Saratovskiy nauchno-meditsinskiy zhurnal. 2020;145–49. (In Russ).
- Leong XF, Ng CY, Badiah B, Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal. 2014;2014:237.
- Sanz M, Marco Del Castillo A, Jepsen S, et al. Periodontitis and cardiovascular diseases: Consensus report. J Clin Periodontol. 2020;47(3):268–288. doi: 10.1111/jcpe.13189
- Khimji AK, Rockey DC. Endothelin-biology and disease. Cell Signal. 2010;22(11):1615–1625. doi: 10.1016/j.cellsig.2010.05.002
- Guo F, Carter DE, Leask A. Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFbeta-dependent mechanism. PLoS One. 2011;6(5):e19756. doi: 10.1371/journal.pone.0019756
- Khalid W, Varghese SS, Sankari M, Jayakumar ND. Comparison of Serum Levels of Endothelin-1 in Chronic Periodontitis Patients Before and After Treatment. J Clin Diagn Res. 2017;11(4):ZC78–ZC81. doi: 10.7860/JCDR/2017/24518.9698
- Li X, Tse HF, Jin LJ. Novel endothelial biomarkers: implications for periodontal disease and CVD. J Dent Res. 2011;90(9):1062–1069. doi: 10.1177/0022034510397194
- Costa ED, Rezende BA, Cortes SF, Lemos VS. Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases. Front Physiol. 2016;7:206. doi: 10.3389/fphys.2016.00206
- Shu X, Keller TCt, Begandt D, et al. Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci. 2015;72(23):4561–4575. doi: 10.1007/s00018-015-2021-0
- Hussain QA, McKay IJ, Gonzales-Marin C, Allaker RP. Regulation of adrenomedullin and nitric oxide production by periodontal bacteria. J Periodontal Res. 2015;50(5):650–657. doi: 10.1111/jre.12246
- Batista AC, Silva TA, Chun JH, Lara VS. Nitric oxide synthesis and severity of human periodontal disease. Oral Dis. 2002;8(5):254–260. doi: 10.1034/j.1601-0825.2002.02852.x
- Reher VG, Zenobio EG, Costa FO, et al. Nitric oxide levels in saliva increase with severity of chronic periodontitis. J Oral Sci. 2007;49(4):271–276. doi: 10.2334/josnusd.49.271
- Lappin DF, Kjeldsen M, Sander L, Kinane DF. Inducible nitric oxide synthase expression in periodontitis. J Periodontal Res. 2000;35(6):369–373. doi: 10.1034/j.1600-0765.2000.035006369.x
- Aurer A, Aleksic J, Ivic-Kardum M, et al. Nitric oxide synthesis is decreased in periodontitis. J Clin Periodontol. 2001;28(6):565–568. doi: 10.1034/j.1600-051x.2001.028006565.x
- Reiter RJ, Tan DX, Fuentes-Broto L. Melatonin: a multitasking molecule. Prog Brain Res. 2010;181:127–151. doi: 10.1016/S0079-6123(08)81008-4
- Srinath R, Acharya AB, Thakur SL. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J Periodontol. 2010;81(2):277–283. doi: 10.1902/jop.2009.090327
- Park KH, Kang JW, Lee EM, et al. Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways. J Pineal Res. 2011;51(2):187–194. doi: 10.1111/j.1600-079X.2011.00875.x