Use of orthodontic treatment protocols in patients with chronic periodontitis and arterial hypertension

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BACKGROUND: The wide prevalence and mutual influence of periodontitis and arterial hypertension determine the importance of choosing a rational approach to denture prosthetics in this patients.

AIM: The study was to choose a rational tactics of dental prosthetics in patients with chronic periodontitis and arterial hypertension based on a clinical and instrumental assessment of the periodontal condition and morphofunctional characteristics of neuroendocrine gum cells.

MATERIALS AND METHODS: The results of the examination of 120 patients with periodontitis and hypertension are presented, of which 90 patients had denture defects, 30 patients — intact dentition. Clinical examination, immunohistochemical, and morphometric studies were performed. 90 patients underwent prosthetics of dentition defects, of which: 32 patients were fitted with metal dentures, 30-metal-ceramic dentures, 28 patients were fitted with thermoplastic resin removable partial dentures.

RESULTS: Periodontitis in patients with hypertension is characterized by more significant changes in the expression of endothelin-1-, melatonin- and endothelial NO-synthase-like cells of gum, than periodontitis in patients without somatic pathology. After periodontal treatment, the use of metal-ceramic dentures and thermoplastic resin removable partial dentures by a year-long persistent remission of periodontitis in 85.7–86.7% of patients is accompanied. Remission is achieved against the background of satisfactory hygiene indicators and restoring the neurotransmitter balance of the oral cavity. After a year of metal dentures, 43.7% of patients report an exacerbation of periodontitis, which by poor hygiene and local neuroendocrine imbalance is facilitated.

CONCLUSION: The use of metal-ceramic dentures and thermoplastic resin removable partial dentures is the preferred option for prosthetics of dentition defects in patients with periodontitis and hypertension.

作者简介

Andrey Eremin

V.I. Razumovsky Saratov State Medical University

Email: pr-ereminav@yandex.ru
ORCID iD: 0000-0002-0457-3303
SPIN 代码: 7561-0020
Researcher ID: AAJ-6804-2021

MD, Cand. Sci. (Med.), assistant professor

俄罗斯联邦, 112, Bolshaya Kazachya str., 410012, Saratov

Aleksandr Lepilin

V.I. Razumovsky Saratov State Medical University

Email: lepilins@mail.ru
ORCID iD: 0000-0001-6940-5178
SPIN 代码: 4293-9439
Scopus 作者 ID: 6603785447
Researcher ID: B-5281-2017

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, 112, Bolshaya Kazachya str., 410012, Saratov

Tatiana Lipatova

V.I. Razumovsky Saratov State Medical University

编辑信件的主要联系方式.
Email: lipatova.t@inbox.ru
ORCID iD: 0000-0002-7401-9930
SPIN 代码: 2483-3578
Scopus 作者 ID: 36892031000
Researcher ID: A-6675-2017

MD, Dr. Sci. (Med.), assistant professor

俄罗斯联邦, 112, Bolshaya Kazachya str., 410012, Saratov

参考

  1. Tsimbalistov AV, Lobanovskaya AA, Mikhailova ES. Diagnostics of intolerance of structural dental materials in the clinic of orthopedic dentistry. Dental South. 2012;(2):30–32. (In Russ).
  2. Hannah VE, O’Donnell L, Robertson D, Ramage G. Denture Stomatitis: Causes, Cures and Prevention. Prim Dent J. 2017;6(4):46–51. doi: 10.1308/205016817822230175
  3. Pravdivtsev VA, Shashmurina VR, Kirillov SK, et al. Pathological processes initiated by metal-ceramic dentures. Russian journal of dentistry. 2013;3:30–34. (In Russ).
  4. Boitsov SA, Shalnova SA, Deev AD. Mortality from cardiovascular diseases in the Russian Federation and possible mechanisms of its change. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2018;8:98–103. (In Russ).
  5. Eremin AV, Lipatova TE, Lepilin AV, Eremin VI. Assessment of cardiovascular risk factors in patients with chronic periodontitis. Saratovskiy nauchno-meditsinskiy zhurnal. 2020;145–49. (In Russ).
  6. Leong XF, Ng CY, Badiah B, Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal. 2014;2014:237.
  7. Sanz M, Marco Del Castillo A, Jepsen S, et al. Periodontitis and cardiovascular diseases: Consensus report. J Clin Periodontol. 2020;47(3):268–288. doi: 10.1111/jcpe.13189
  8. Khimji AK, Rockey DC. Endothelin-biology and disease. Cell Signal. 2010;22(11):1615–1625. doi: 10.1016/j.cellsig.2010.05.002
  9. Guo F, Carter DE, Leask A. Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFbeta-dependent mechanism. PLoS One. 2011;6(5):e19756. doi: 10.1371/journal.pone.0019756
  10. Khalid W, Varghese SS, Sankari M, Jayakumar ND. Comparison of Serum Levels of Endothelin-1 in Chronic Periodontitis Patients Before and After Treatment. J Clin Diagn Res. 2017;11(4):ZC78–ZC81. doi: 10.7860/JCDR/2017/24518.9698
  11. Li X, Tse HF, Jin LJ. Novel endothelial biomarkers: implications for periodontal disease and CVD. J Dent Res. 2011;90(9):1062–1069. doi: 10.1177/0022034510397194
  12. Costa ED, Rezende BA, Cortes SF, Lemos VS. Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases. Front Physiol. 2016;7:206. doi: 10.3389/fphys.2016.00206
  13. Shu X, Keller TCt, Begandt D, et al. Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci. 2015;72(23):4561–4575. doi: 10.1007/s00018-015-2021-0
  14. Hussain QA, McKay IJ, Gonzales-Marin C, Allaker RP. Regulation of adrenomedullin and nitric oxide production by periodontal bacteria. J Periodontal Res. 2015;50(5):650–657. doi: 10.1111/jre.12246
  15. Batista AC, Silva TA, Chun JH, Lara VS. Nitric oxide synthesis and severity of human periodontal disease. Oral Dis. 2002;8(5):254–260. doi: 10.1034/j.1601-0825.2002.02852.x
  16. Reher VG, Zenobio EG, Costa FO, et al. Nitric oxide levels in saliva increase with severity of chronic periodontitis. J Oral Sci. 2007;49(4):271–276. doi: 10.2334/josnusd.49.271
  17. Lappin DF, Kjeldsen M, Sander L, Kinane DF. Inducible nitric oxide synthase expression in periodontitis. J Periodontal Res. 2000;35(6):369–373. doi: 10.1034/j.1600-0765.2000.035006369.x
  18. Aurer A, Aleksic J, Ivic-Kardum M, et al. Nitric oxide synthesis is decreased in periodontitis. J Clin Periodontol. 2001;28(6):565–568. doi: 10.1034/j.1600-051x.2001.028006565.x
  19. Reiter RJ, Tan DX, Fuentes-Broto L. Melatonin: a multitasking molecule. Prog Brain Res. 2010;181:127–151. doi: 10.1016/S0079-6123(08)81008-4
  20. Srinath R, Acharya AB, Thakur SL. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J Periodontol. 2010;81(2):277–283. doi: 10.1902/jop.2009.090327
  21. Park KH, Kang JW, Lee EM, et al. Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways. J Pineal Res. 2011;51(2):187–194. doi: 10.1111/j.1600-079X.2011.00875.x

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2. Fig. Gum biopsy. Patient S., 48 years old. Diagnosis: Chronic generalized periodontitis of moderate severity. Arterial hypertension. An increase in the number of cells immunopositive to endothelin-1 is determined mainly in the vascular wall. Immunohistochemical method with antibodies to endothelin-1. ×400

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