Stability of Chromatin Remodeling Complex Subunits Is Determined by Their Phosphorylation Status

A. M. Azieva; A. A. Sheinov; F. A. Galkin; S. G. Georgieva; N. V. Soshnikova

doi:10.1134/S1607672918020035

Stability of Chromatin Remodeling Complex Subunits Is Determined by Their Phosphorylation Status

Авторлар: Azieva A.M.¹^,2, Sheinov A.A.¹, Galkin F.A.¹, Georgieva S.G.³, Soshnikova N.V.¹
Мекемелер:
1. Institute of Gene Biology
2. Kurchatov Institute National Research Center
3. Engelhardt Institute of Molecular Biology
Шығарылым: Том 479, № 1 (2018)
Беттер: 66-68
Бөлім: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212140
DOI: https://doi.org/10.1134/S1607672918020035
ID: 212140

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Аннотация

It was found that, in the differentiated cells of mouse brain, the level of core (Brg1 and BAF155) and specific (BRD7, BAF180, and PHF10) subunits of the chromatin-remodeling complex PBAF is reduced compared to the undifferentiated proliferating cells. Phosphorylation of PBAF complex subunits is required for maintaining their stability in differentiated brain cells.