Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells

Аннотация

It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10^–7 and 10^–3 M and piracetam at a concentration of 10^–3 M increased the content of brainderived neurotrophic factor (BDNF) in the culture of neuronal cells in normal state and under conditions of glutamate and 6-oxydopamine neurotoxicity. This may indicate the possible involvement of BDNF in the mechanism of action of neuropeptide CPG and piracetam.