Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells

T. A. Gudasheva; K. N. Koliasnikova; T. A. Antipova; S. B. Seredenin

doi:10.1134/S1607672916040104

Neuropeptide cycloprolylglycine increases the levels of brain-derived neurotrophic factor in neuronal cells

Autores: Gudasheva T.A.¹, Koliasnikova K.N.¹, Antipova T.A.¹, Seredenin S.B.¹
Afiliações:
1. Zakusov Research Institute of Pharmacology
Edição: Volume 469, Nº 1 (2016)
Páginas: 273-276
Seção: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211419
DOI: https://doi.org/10.1134/S1607672916040104
ID: 211419

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It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10^–7 and 10^–3 M and piracetam at a concentration of 10^–3 M increased the content of brainderived neurotrophic factor (BDNF) in the culture of neuronal cells in normal state and under conditions of glutamate and 6-oxydopamine neurotoxicity. This may indicate the possible involvement of BDNF in the mechanism of action of neuropeptide CPG and piracetam.