Features of the gas transport function of blood in hyperpigmentations of the skin
- 作者: Glushkova M.1, Sarkisian O.1, Sidorenko O.1, Stradanchenko A.1
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隶属关系:
- Rostov State Medical University
- 期: 卷 27, 编号 2 (2024)
- 页面: 169-177
- 栏目: DERMATOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/262156
- DOI: https://doi.org/10.17816/dv625403
- ID: 262156
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详细
BACKGROUND: Acquired hyperpigmentation is widespread in the population and significantly affects the quality of life of the patients. It is known that one of the clinical signs of skin hyperpigmentation is localized hyperkeratosis in the lesion associated with a high level of cell proliferation and cell saturation with melanin. Cellular proliferation and hyperkeratosis are associated with increased local metabolism rates.
AIM: Study of erythrocyte gas transport function in women with skin hyperpigmentation compared to the control group.
MATERIALS AND METHODS: To achieve the objective, the concentrations of lactic acid, pyruvic acid and 2,3-diphosphoglycerate levels in venous blood erythrocytes were investigated.
RESULTS: The phenomenon of skin hyperpigmentation is accompanied by a restructuring of blood cell metabolism aimed at preserving oxygen and energy homeostasis of skin structures. The obtained data indicate redistribution of oxygen in cellular structures and tissues, which is accompanied by a significant increase in lactate concentration and formation of local tissue hypoxia.
CONCLUSION: The formation of skin pigmentation is considered as a physiological mechanism in response to inflammation, mainly associated with ultraviolet radiation. The general strategy of the course of the inflammatory process under normal regulation or dysregulation has similar features, but there are also differences. It seems necessary to further study systemic adaptation mechanisms in dysregulation and formation of skin hyperpigmentation.
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作者简介
Maria Glushkova
Rostov State Medical University
编辑信件的主要联系方式.
Email: mariaglushkova06@gmail.com
ORCID iD: 0009-0000-2926-8113
俄罗斯联邦, Rostov-on-Don
Oleg Sarkisian
Rostov State Medical University
Email: sarkisian_og@rostgmu.ru
ORCID iD: 0000-0001-5293-986X
MD, Dr. Sci. (Med.), Associate Professor
俄罗斯联邦, Rostov-on-DonOlga Sidorenko
Rostov State Medical University
Email: ola_ps@mail.ru
ORCID iD: 0000-0002-7387-2497
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, Rostov-on-DonAnastasia Stradanchenko
Rostov State Medical University
Email: ola_ps@mail.ru
俄罗斯联邦, Rostov-on-Don
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