Features of the gas transport function of blood in hyperpigmentations of the skin
- Authors: Glushkova M.V.1, Sarkisian O.G.1, Sidorenko O.A.1, Stradanchenko A.S.1
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Affiliations:
- Rostov State Medical University
- Issue: Vol 27, No 2 (2024)
- Pages: 169-177
- Section: DERMATOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/262156
- DOI: https://doi.org/10.17816/dv625403
- ID: 262156
Cite item
Abstract
BACKGROUND: Acquired hyperpigmentation is widespread in the population and significantly affects the quality of life of the patients. It is known that one of the clinical signs of skin hyperpigmentation is localized hyperkeratosis in the lesion associated with a high level of cell proliferation and cell saturation with melanin. Cellular proliferation and hyperkeratosis are associated with increased local metabolism rates.
AIM: Study of erythrocyte gas transport function in women with skin hyperpigmentation compared to the control group.
MATERIALS AND METHODS: To achieve the objective, the concentrations of lactic acid, pyruvic acid and 2,3-diphosphoglycerate levels in venous blood erythrocytes were investigated.
RESULTS: The phenomenon of skin hyperpigmentation is accompanied by a restructuring of blood cell metabolism aimed at preserving oxygen and energy homeostasis of skin structures. The obtained data indicate redistribution of oxygen in cellular structures and tissues, which is accompanied by a significant increase in lactate concentration and formation of local tissue hypoxia.
CONCLUSION: The formation of skin pigmentation is considered as a physiological mechanism in response to inflammation, mainly associated with ultraviolet radiation. The general strategy of the course of the inflammatory process under normal regulation or dysregulation has similar features, but there are also differences. It seems necessary to further study systemic adaptation mechanisms in dysregulation and formation of skin hyperpigmentation.
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##article.viewOnOriginalSite##About the authors
Maria V. Glushkova
Rostov State Medical University
Author for correspondence.
Email: mariaglushkova06@gmail.com
ORCID iD: 0009-0000-2926-8113
Russian Federation, Rostov-on-Don
Oleg G. Sarkisian
Rostov State Medical University
Email: sarkisian_og@rostgmu.ru
ORCID iD: 0000-0001-5293-986X
MD, Dr. Sci. (Med.), Associate Professor
Russian Federation, Rostov-on-DonOlga A. Sidorenko
Rostov State Medical University
Email: ola_ps@mail.ru
ORCID iD: 0000-0002-7387-2497
MD, Dr. Sci. (Med.), Professor
Russian Federation, Rostov-on-DonAnastasia S. Stradanchenko
Rostov State Medical University
Email: ola_ps@mail.ru
Russian Federation, Rostov-on-Don
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