INFLUENCE OF ANTIARRHYTHMIC DRUGS ON THE SPECTRAL ANALYSIS OF HEART RATE VARIABILITY IN PATIENTS WITH ATRIAL FIBRILLATION


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Abstract

The use of the spectral analysis of the heart rate variability to assess the effectiveness of therapy is of great attention of researchers and doctors. This method allows you to get knowledge of the influence of the autonomic nervous system on the heart activity, which is an important factor for the manifestation of the effects of antiarrhythmic drugs. In this study, we studied the effect of antiarrhythmic drugs of class III amiodarone and sotalol on spectral indices of the heart rate variability in patients with atrial fibrillation. The power of slow frequencies prevailed in the structure of the spectrum with the introduction of amiodarone and sotalol. This suggests that the sympathetic nervous system have a predominant influence on the heart.

About the authors

Ekaterina P. Popova

I.M. Sechenov First Moscow State Medical University

Email: kispo-pharm@mail.ru
MD, PhD, Associate Professor of the Department of Pharmacology, Moscow, 119435, Russian Federation Moscow, 119435, Russian Federation

O. T Bogova

Russian Medical Academy of Continuous Professional Education

Moscow, 125993, Russian Federation

S. N Puzin

Russian Medical Academy of Continuous Professional Education

Moscow, 125993, Russian Federation

I. S Matsokin

Municipal Clinical Hospital № 24

Moscow, 127015, Russian Federation

A. A Gadzhimagomedova

Russian Medical Academy of Continuous Professional Education

Moscow, 125993, Russian Federation

D. A Sychev

Russian Medical Academy of Continuous Professional Education

Moscow, 125993, Russian Federation

V. P Fisenko

I.M. Sechenov First Moscow State Medical University

Moscow, 119435, Russian Federation

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