Halocyclization of 2-allyl(propargyl)sulfanyl-6-aminopyrimidin-4(3H)-ones

详细

The alkylation of 6-amino-2-thiouracil with allyl, methallyl, and propargyl halides in the presence of bases gave 2-[allyl(methallyl, propargyl)sulfanyl]-6-aminopyrimidin-4(3H)-ones which reacted with iodine and bromine to form fused [1,3]thiazolo[3,2-a]pyrimidinium systems. Their nitrosation with sodium nitrite in acid medium afforded 2-[allyl(propargyl)sulfanyl]-6-amino-5-nitrosopyrimidin-4(3H)-ones.