Отправить статью по E-mail Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone
- Авторы: Jassem A.M.1, Raheemah A.H.2, Radhi W.A.3, Alid A.M.4, Jaber H.A.1
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Учреждения:
- Department of Chemistry, College of Education for Pure Sciences
- Department of Chemistry, College of Science
- Department of Chemistry, Polymer Research Center
- Department of Material Science, Polymer Research Center
- Выпуск: Том 55, № 10 (2019)
- Страницы: 1598-1603
- Раздел: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/221304
- DOI: https://doi.org/10.1134/S107042801910021X
- ID: 221304
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Аннотация
A four-step procedure has been developed for the synthesis of (S)-3-isopropyl-1-[(R)-1-phenylethyl)- 1,4-diazaspiro[4.5]decan-2-one with high diastereoselectivity (up to 95% de) from (S)-α-aminoisovaleric acid (L-valine). Quantum chemical computations of the synthesized compound have been performed using Gaussian 09 software package.
Об авторах
A. Jassem
Department of Chemistry, College of Education for Pure Sciences
Автор, ответственный за переписку.
Email: ahmedmajeedhsskia@gmail.com
Ирак, Basrah
A. Raheemah
Department of Chemistry, College of Science
Email: ahmedmajeedhsskia@gmail.com
Ирак, Baghdad
W. Radhi
Department of Chemistry, Polymer Research Center
Email: ahmedmajeedhsskia@gmail.com
Ирак, Basrah
A. Alid
Department of Material Science, Polymer Research Center
Email: ahmedmajeedhsskia@gmail.com
Ирак, Basrah
H. Jaber
Department of Chemistry, College of Education for Pure Sciences
Email: ahmedmajeedhsskia@gmail.com
Ирак, Basrah
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