Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone

A. M. Jassem; A. H. Raheemah; W. A. Radhi; A. M. Alid; H. A. Jaber

doi:10.1134/S107042801910021X

Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone

作者: Jassem A.M.¹, Raheemah A.H.², Radhi W.A.³, Alid A.M.⁴, Jaber H.A.¹
隶属关系:
1. Department of Chemistry, College of Education for Pure Sciences
2. Department of Chemistry, College of Science
3. Department of Chemistry, Polymer Research Center
4. Department of Material Science, Polymer Research Center
期: 卷 55, 编号 10 (2019)
页面: 1598-1603
栏目: Article
URL: https://journals.rcsi.science/1070-4280/article/view/221304
DOI: https://doi.org/10.1134/S107042801910021X
ID: 221304

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详细

A four-step procedure has been developed for the synthesis of (S)-3-isopropyl-1-[(R)-1-phenylethyl)- 1,4-diazaspiro[4.5]decan-2-one with high diastereoselectivity (up to 95% de) from (S)-α-aminoisovaleric acid (L-valine). Quantum chemical computations of the synthesized compound have been performed using Gaussian 09 software package.