Email this article Highly Diastereoselective Metal-Free Catalytic Synthesis of Drug-Like Spiroimidazolidinone
- Authors: Jassem A.M.1, Raheemah A.H.2, Radhi W.A.3, Alid A.M.4, Jaber H.A.1
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Affiliations:
- Department of Chemistry, College of Education for Pure Sciences
- Department of Chemistry, College of Science
- Department of Chemistry, Polymer Research Center
- Department of Material Science, Polymer Research Center
- Issue: Vol 55, No 10 (2019)
- Pages: 1598-1603
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/221304
- DOI: https://doi.org/10.1134/S107042801910021X
- ID: 221304
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Abstract
A four-step procedure has been developed for the synthesis of (S)-3-isopropyl-1-[(R)-1-phenylethyl)- 1,4-diazaspiro[4.5]decan-2-one with high diastereoselectivity (up to 95% de) from (S)-α-aminoisovaleric acid (L-valine). Quantum chemical computations of the synthesized compound have been performed using Gaussian 09 software package.
About the authors
A. M. Jassem
Department of Chemistry, College of Education for Pure Sciences
Author for correspondence.
Email: ahmedmajeedhsskia@gmail.com
Iraq, Basrah
A. H. Raheemah
Department of Chemistry, College of Science
Email: ahmedmajeedhsskia@gmail.com
Iraq, Baghdad
W. A. Radhi
Department of Chemistry, Polymer Research Center
Email: ahmedmajeedhsskia@gmail.com
Iraq, Basrah
A. M. Alid
Department of Material Science, Polymer Research Center
Email: ahmedmajeedhsskia@gmail.com
Iraq, Basrah
H. A. Jaber
Department of Chemistry, College of Education for Pure Sciences
Email: ahmedmajeedhsskia@gmail.com
Iraq, Basrah
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