Enviar artigo por via de e-mail Study by inverse gas chromatography of the solubility of rifabutin in water in the presence of cyclodextrin
- Autores: Anshakova A.V.1, Konyukhov V.Y.1
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Afiliações:
- Dmitry Mendeleev University of Chemical Technology of Russia
- Edição: Volume 90, Nº 2 (2017)
- Páginas: 209-213
- Seção: Physicochemical Studies of Systems and Processes
- URL: https://journals.rcsi.science/1070-4272/article/view/214707
- DOI: https://doi.org/10.1134/S1070427217020082
- ID: 214707
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Resumo
Inverse gas chromatography was used to study the stability of rifabutin and cyclodextrin complexes in water. The thermodynamic mixing functions were determined in the system rifabutin‒cyclodextrin‒water. Addition of hydroxypropyl-β-cyclodextrin to rifabutin creates in water a thermodynamically stable complex, with the solubility of rifabutin in water thereby raised and this antibiotic made more bioavailable in curing of tuberculosis.
Sobre autores
A. Anshakova
Dmitry Mendeleev University of Chemical Technology of Russia
Autor responsável pela correspondência
Email: anshakova_a@mail.ru
Rússia, ul. Miusskaya 9, Moscow, 125047
V. Konyukhov
Dmitry Mendeleev University of Chemical Technology of Russia
Email: anshakova_a@mail.ru
Rússia, ul. Miusskaya 9, Moscow, 125047
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