Email this article Study by inverse gas chromatography of the solubility of rifabutin in water in the presence of cyclodextrin
- Authors: Anshakova A.V.1, Konyukhov V.Y.1
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Affiliations:
- Dmitry Mendeleev University of Chemical Technology of Russia
- Issue: Vol 90, No 2 (2017)
- Pages: 209-213
- Section: Physicochemical Studies of Systems and Processes
- URL: https://journals.rcsi.science/1070-4272/article/view/214707
- DOI: https://doi.org/10.1134/S1070427217020082
- ID: 214707
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Abstract
Inverse gas chromatography was used to study the stability of rifabutin and cyclodextrin complexes in water. The thermodynamic mixing functions were determined in the system rifabutin‒cyclodextrin‒water. Addition of hydroxypropyl-β-cyclodextrin to rifabutin creates in water a thermodynamically stable complex, with the solubility of rifabutin in water thereby raised and this antibiotic made more bioavailable in curing of tuberculosis.
About the authors
A. V. Anshakova
Dmitry Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: anshakova_a@mail.ru
Russian Federation, ul. Miusskaya 9, Moscow, 125047
V. Yu. Konyukhov
Dmitry Mendeleev University of Chemical Technology of Russia
Email: anshakova_a@mail.ru
Russian Federation, ul. Miusskaya 9, Moscow, 125047
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