Study by inverse gas chromatography of the solubility of rifabutin in water in the presence of cyclodextrin

详细

Inverse gas chromatography was used to study the stability of rifabutin and cyclodextrin complexes in water. The thermodynamic mixing functions were determined in the system rifabutin‒cyclodextrin‒water. Addition of hydroxypropyl-β-cyclodextrin to rifabutin creates in water a thermodynamically stable complex, with the solubility of rifabutin in water thereby raised and this antibiotic made more bioavailable in curing of tuberculosis.