New Pyridopyrimidone Derivatives: Synthesis, Molecular Docking Studies, and Potential Anticancer Activity
- 作者: Khalifa N.1,2, Alkahtani H.3, Al-Omar M.1,3, Bakheit A.3,4
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隶属关系:
- Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy
- Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division
- Pharmaceutical Chemistry Department, College of Pharmacy
- Chemistry Department, Faculty of Science and Technology
- 期: 卷 89, 编号 8 (2019)
- 页面: 1683-1690
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223044
- DOI: https://doi.org/10.1134/S107036321908022X
- ID: 223044
如何引用文章
详细
A new series of pyrido[2,3-d]pyrimidones incorporated pyrazoles and fused triazoles are synthesized and tested in vitro for cytotoxic effect against cancer cell lines: HePG-2, HCT-116, MCF-7, PC-3, and A-549. Their inhibition of protein kinase is assessed. The highest growth inhibitory (IC50 0.3 µM) effect is determined for one of compounds as compared with doxorubicin (IC50 0.6 µM). A modeling study is performed for approaching the compounds mode of binding and their similarity with the positive control drugs.
作者简介
N. Khalifa
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division
编辑信件的主要联系方式.
Email: nkhalifa.c@ksu.edu.sa
沙特阿拉伯, Riyadh, 11451; Giza, Cairo, 12622
H. Alkahtani
Pharmaceutical Chemistry Department, College of Pharmacy
Email: nkhalifa.c@ksu.edu.sa
沙特阿拉伯, Riyadh, 11451
M. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Pharmaceutical Chemistry Department, College of Pharmacy
Email: nkhalifa.c@ksu.edu.sa
沙特阿拉伯, Riyadh, 11451; Riyadh, 11451
A. Bakheit
Pharmaceutical Chemistry Department, College of Pharmacy; Chemistry Department, Faculty of Science and Technology
Email: nkhalifa.c@ksu.edu.sa
沙特阿拉伯, Riyadh, 11451; Khartoum
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