Synthesis and Anticancer Activity of Thiophene-2-carboxamide Derivatives and In Silico Docking Studies
- 作者: Gulipalli K.1, Ravula P.2, Bodige S.1, Endoori S.1, Cherukumalli P.1, Narendra Sharath Chandra J.3, Seelam N.1
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隶属关系:
- Department of Chemistry
- Department of Pharmaceutical Chemistry, Gurunanak Institutions Technical Campus
- Department of Pharmaceutical Chemistry
- 期: 卷 89, 编号 7 (2019)
- 页面: 1502-1512
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223002
- DOI: https://doi.org/10.1134/S1070363219070211
- ID: 223002
如何引用文章
详细
A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectra. The synthesized compounds are evaluated for their in vitro cytotoxic activity by MTT assay. Among the tested compounds, the derivative with 4-Cl-phenyl ring exhibits potent inhibitory activity against MCF-7, K562, HepG2, and MDA-MB-231. The molecular docking study performed for the synthesized compounds against PTP1B exhibits essential key interactions.
作者简介
K. Gulipalli
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Green Fields, Vaddeswaram, Guntur, 522502
P. Ravula
Department of Pharmaceutical Chemistry, Gurunanak Institutions Technical Campus
Email: nareshvarma.klu@gmail.com
印度, Hyderabad, 501506
S. Bodige
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Green Fields, Vaddeswaram, Guntur, 522502
S. Endoori
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Green Fields, Vaddeswaram, Guntur, 522502
P. Cherukumalli
Department of Chemistry
Email: nareshvarma.klu@gmail.com
印度, Green Fields, Vaddeswaram, Guntur, 522502
J. Narendra Sharath Chandra
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
印度, Majalgaon, Maharashtra, 431129
N. Seelam
Department of Chemistry
编辑信件的主要联系方式.
Email: nareshvarma.klu@gmail.com
印度, Green Fields, Vaddeswaram, Guntur, 522502
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