Synthesis and Anticancer Activity of Thiophene-2-carboxamide Derivatives and In Silico Docking Studies
- Authors: Gulipalli K.C.1, Ravula P.2, Bodige S.1, Endoori S.1, Cherukumalli P.K.1, Narendra Sharath Chandra J.N.3, Seelam N.1
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Affiliations:
- Department of Chemistry
- Department of Pharmaceutical Chemistry, Gurunanak Institutions Technical Campus
- Department of Pharmaceutical Chemistry
- Issue: Vol 89, No 7 (2019)
- Pages: 1502-1512
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223002
- DOI: https://doi.org/10.1134/S1070363219070211
- ID: 223002
Cite item
Abstract
A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectra. The synthesized compounds are evaluated for their in vitro cytotoxic activity by MTT assay. Among the tested compounds, the derivative with 4-Cl-phenyl ring exhibits potent inhibitory activity against MCF-7, K562, HepG2, and MDA-MB-231. The molecular docking study performed for the synthesized compounds against PTP1B exhibits essential key interactions.
About the authors
K. C. Gulipalli
Department of Chemistry
Email: nareshvarma.klu@gmail.com
India, Green Fields, Vaddeswaram, Guntur, 522502
P. Ravula
Department of Pharmaceutical Chemistry, Gurunanak Institutions Technical Campus
Email: nareshvarma.klu@gmail.com
India, Hyderabad, 501506
S. Bodige
Department of Chemistry
Email: nareshvarma.klu@gmail.com
India, Green Fields, Vaddeswaram, Guntur, 522502
S. Endoori
Department of Chemistry
Email: nareshvarma.klu@gmail.com
India, Green Fields, Vaddeswaram, Guntur, 522502
P. K. R. Cherukumalli
Department of Chemistry
Email: nareshvarma.klu@gmail.com
India, Green Fields, Vaddeswaram, Guntur, 522502
J. N. Narendra Sharath Chandra
Department of Pharmaceutical Chemistry
Email: nareshvarma.klu@gmail.com
India, Majalgaon, Maharashtra, 431129
N. Seelam
Department of Chemistry
Author for correspondence.
Email: nareshvarma.klu@gmail.com
India, Green Fields, Vaddeswaram, Guntur, 522502