Synthesis, Antibacterial Activity, and Cytotoxicity of Newly Synthesized N-Substituted 5,6-Dimethoxy-1H-indole Derivatives
- 作者: Raghavender M.1, Shankar B.1, Jalapathi P.1, Perugu S.2
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隶属关系:
- Department of Chemistry
- Department of Biotechnology
- 期: 卷 89, 编号 7 (2019)
- 页面: 1496-1501
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223000
- DOI: https://doi.org/10.1134/S107036321907020X
- ID: 223000
如何引用文章
详细
A series of novel functionalized N-substituted 5, 6-dimethoxy-1H-indole derivatives is synthesized. All products are evaluated for antibacterial activity using rifampicin and ciprofloxacin as standard drugs and identified as the promising compounds for further studies. The products are screened for their anticancer activity against MCF7 cell line (breast cancer cell-line) using MTT assay. Two compounds display a significant activity against MCF7 cell line at a very low concentration. The structure-cytotoxicity relationship is supported by molecular docking studies of the active compounds against 3S7S receptor.
作者简介
M. Raghavender
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, Telagana, 500007
B. Shankar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, Telagana, 500004
P. Jalapathi
Department of Chemistry
编辑信件的主要联系方式.
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, Telagana, 500007
S. Perugu
Department of Biotechnology
Email: pochampalli.ou.chemi@gmail.com
印度, Warangal, Telagana, 506001
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