Efficient Synthesis of New Pyrimido[5′,4′:5,6]pyrano[2,3-d]pyrimidine-2,4,6(1H,3H)-triones via the Tandem Intramolecular Pinner–Dimroth Rearrangement, and Their Antibacterial Activity
- 作者: Asadian M.1, Davoodnia A.1, Beyramabadi S.1
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隶属关系:
- Department of Chemistry, Mashhad Branch
- 期: 卷 88, 编号 12 (2018)
- 页面: 2658-2663
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222613
- DOI: https://doi.org/10.1134/S1070363218120290
- ID: 222613
如何引用文章
详细
Synthesis of new 8-alkyl-5-aryl-1,3-dimethyl-5,7-dihydro-2H-pyrimido[5′,4′:5,6]pyrano[2,3-d]- pyrimidine-2,4,6(1H,3H)-triones by the high yield reaction of 7-amino-5-aryl-1,3-dimethyl-2,4-dioxo-1,3,4,5- tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitriles with aliphatic carboxylic acids in the presence of POCl3 is presented. It is probable that synthesis of these new products proceeds via the tandem intramolecular Pinner–Dimroth rearrangement. The products are characterized by FT-IR, 1H, and 13C NMR spectra and evaluated for their antibacterial activity against gram +ve bacteria (Staphylococcus aureus and Staphylococcus epidermidis) and gram–ve bacteria (Escherichia coli and Pseudomonas aeruginosa) using the disc diffusion method.
作者简介
M. Asadian
Department of Chemistry, Mashhad Branch
Email: adavoodnia@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad, 9175687119
A. Davoodnia
Department of Chemistry, Mashhad Branch
编辑信件的主要联系方式.
Email: adavoodnia@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad, 9175687119
S. Beyramabadi
Department of Chemistry, Mashhad Branch
Email: adavoodnia@mshdiau.ac.ir
伊朗伊斯兰共和国, Mashhad, 9175687119
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