Novel Bis(1,2,4-oxadiazolyl) Fused Thiazole Derivatives: Synthesis and Anticancer Activity
- 作者: Sateesh Kumar P.1, Umadevi P.1
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隶属关系:
- Department of Chemistry, Gitam Institute of Sciences
- 期: 卷 88, 编号 12 (2018)
- 页面: 2611-2615
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222603
- DOI: https://doi.org/10.1134/S107036321812023X
- ID: 222603
如何引用文章
详细
A novel series of bis-1,2,4-oxadiazole fused benzothiazole derivatives 9a–9j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. All products are evaluated in vitro for their anticancer potential against a panel of four human cancer cell lines such as lung cancer (A549), breast carcinoma (MCF-7), melanoma (A375), and colon cancer (HT-29). The combretastatin-A4 is used as standard drug. All compounds 9a–9j exhibit significant anticancer activity with IC50 values ranging from 0.11±0.01 to 14.6±3.89 μM. Among these, compounds 9a–9d, 9h, 9i demonstrate more potent activity than the control.
作者简介
P. Sateesh Kumar
Department of Chemistry, Gitam Institute of Sciences
Email: sateeshpinninti@rediffmail.com
印度, Rushikonda, Vishakapatnam, 530045
P. Umadevi
Department of Chemistry, Gitam Institute of Sciences
编辑信件的主要联系方式.
Email: sateeshpinninti@rediffmail.com
印度, Rushikonda, Vishakapatnam, 530045