Novel Bis(1,2,4-oxadiazolyl) Fused Thiazole Derivatives: Synthesis and Anticancer Activity
- Authors: Sateesh Kumar P.1, Umadevi P.1
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Affiliations:
- Department of Chemistry, Gitam Institute of Sciences
- Issue: Vol 88, No 12 (2018)
- Pages: 2611-2615
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222603
- DOI: https://doi.org/10.1134/S107036321812023X
- ID: 222603
Cite item
Abstract
A novel series of bis-1,2,4-oxadiazole fused benzothiazole derivatives 9a–9j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. All products are evaluated in vitro for their anticancer potential against a panel of four human cancer cell lines such as lung cancer (A549), breast carcinoma (MCF-7), melanoma (A375), and colon cancer (HT-29). The combretastatin-A4 is used as standard drug. All compounds 9a–9j exhibit significant anticancer activity with IC50 values ranging from 0.11±0.01 to 14.6±3.89 μM. Among these, compounds 9a–9d, 9h, 9i demonstrate more potent activity than the control.
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About the authors
P. Sateesh Kumar
Department of Chemistry, Gitam Institute of Sciences
Email: sateeshpinninti@rediffmail.com
India, Rushikonda, Vishakapatnam, 530045
P. Umadevi
Department of Chemistry, Gitam Institute of Sciences
Author for correspondence.
Email: sateeshpinninti@rediffmail.com
India, Rushikonda, Vishakapatnam, 530045