Synthesis and Some Transformations of (2,2-Dimethyl-4-propyltetrahydro-2H-pyran-4-yl)acetonitrile
- 作者: Arutyunyan N.1, Akopyan L.1, Akopyan N.1, Panosyan G.2, Gevorgyan G.1
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隶属关系:
- Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- 期: 卷 88, 编号 7 (2018)
- 页面: 1537-1541
- 栏目: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222341
- DOI: https://doi.org/10.1134/S1070363218070290
- ID: 222341
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详细
Removal of the ethoxycarbonyl group in ethyl cyano-(2,2-dimethyl-4-propyltetrahydro-2H-pyran-4 -yl)acetate afforded the corresponding (2,2-dimethyl-4-propyltetrahydro-2H-pyran-4-yl)acetonitrile. The reduction of the latter with lithium aluminum hydride furnished 2-(2,2-dimethyl-4-propyltetrahydro-2H-pyran- 4-yl)ethanamine, which reacted with furfural and a heterocyclic ketone followed by reduction to form the secondary amines and some amides. Hydrolysis of the above nitrile resulted in the corresponding acid, which was converted in a series of amides.
作者简介
N. Arutyunyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014
L. Akopyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014
N. Akopyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014
G. Panosyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
亚美尼亚, Yerevan
G. Gevorgyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
编辑信件的主要联系方式.
Email: gyulgev@gmail.com
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014