Synthesis and Some Transformations of (2,2-Dimethyl-4-propyltetrahydro-2H-pyran-4-yl)acetonitrile
- Autores: Arutyunyan N.1, Akopyan L.1, Akopyan N.1, Panosyan G.2, Gevorgyan G.1
-
Afiliações:
- Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Edição: Volume 88, Nº 7 (2018)
- Páginas: 1537-1541
- Seção: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/222341
- DOI: https://doi.org/10.1134/S1070363218070290
- ID: 222341
Citar
Resumo
Removal of the ethoxycarbonyl group in ethyl cyano-(2,2-dimethyl-4-propyltetrahydro-2H-pyran-4 -yl)acetate afforded the corresponding (2,2-dimethyl-4-propyltetrahydro-2H-pyran-4-yl)acetonitrile. The reduction of the latter with lithium aluminum hydride furnished 2-(2,2-dimethyl-4-propyltetrahydro-2H-pyran- 4-yl)ethanamine, which reacted with furfural and a heterocyclic ketone followed by reduction to form the secondary amines and some amides. Hydrolysis of the above nitrile resulted in the corresponding acid, which was converted in a series of amides.
Palavras-chave
Sobre autores
N. Arutyunyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armênia, pr. Azatutyan 26, Yerevan, 0014
L. Akopyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armênia, pr. Azatutyan 26, Yerevan, 0014
N. Akopyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armênia, pr. Azatutyan 26, Yerevan, 0014
G. Panosyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: gyulgev@gmail.com
Armênia, Yerevan
G. Gevorgyan
Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Autor responsável pela correspondência
Email: gyulgev@gmail.com
Armênia, pr. Azatutyan 26, Yerevan, 0014