Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Linked Imidazothiadiazole Derivatives
- 作者: Chakrapani B.1, Ramesh V.1, Pourna Chander Rao G.1, Ramachandran D.1, Madhukar Reddy T.2, Kalyan Chakravarthy A.3, Sridhar G.4
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隶属关系:
- Department of Chemistry
- Department of Physical Sciences
- Dr. Reddy’s Laboratories
- Organic and Biomolecular Chemistry Division, Council of Scientific and Industrial Research
- 期: 卷 88, 编号 5 (2018)
- 页面: 1020-1024
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222212
- DOI: https://doi.org/10.1134/S1070363218050304
- ID: 222212
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详细
A series of 1,2,4-oxadiazole linked imidazothiadiazole derivatives 11a–11j have been synthesized. All derivatives were evaluated for anticancer activity against three human cancer cell lines (A375, MCF-7, and ACHN) and demonstrated activity comparable with that of doxorubicin. Three compounds 11b, 11c, and 11j exhibited higher anticancer activity than the positive control. The range of IC50 for the compounds 11b, 11c, and 11j is determined to be from 0.11 to 2.98 μM.
作者简介
B. Chakrapani
Department of Chemistry
Email: rk1org@yahoo.com
印度, Guntur, Andhra Pradesh
V. Ramesh
Department of Chemistry
Email: rk1org@yahoo.com
印度, Guntur, Andhra Pradesh
G. Pourna Chander Rao
Department of Chemistry
Email: rk1org@yahoo.com
印度, Guntur, Andhra Pradesh
D. Ramachandran
Department of Chemistry
Email: rk1org@yahoo.com
印度, Guntur, Andhra Pradesh
T. Madhukar Reddy
Department of Physical Sciences
Email: rk1org@yahoo.com
印度, Hasanparthy, Telangana, Warangal District
A. Kalyan Chakravarthy
Dr. Reddy’s Laboratories
编辑信件的主要联系方式.
Email: rk1org@yahoo.com
印度, Bachupally, Hyderabad
Gattu Sridhar
Organic and Biomolecular Chemistry Division, Council of Scientific and Industrial Research
Email: rk1org@yahoo.com
印度, Hyderabad, 500107