Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Linked Imidazothiadiazole Derivatives

B. Chakrapani; V. Ramesh; G. Pourna Chander Rao; D. Ramachandran; T. Madhukar Reddy; A. Kalyan Chakravarthy; Gattu Sridhar

doi:10.1134/S1070363218050304

Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Linked Imidazothiadiazole Derivatives

Autores: Chakrapani B.¹, Ramesh V.¹, Pourna Chander Rao G.¹, Ramachandran D.¹, Madhukar Reddy T.², Kalyan Chakravarthy A.³, Sridhar G.⁴
Afiliações:
1. Department of Chemistry
2. Department of Physical Sciences
3. Dr. Reddy’s Laboratories
4. Organic and Biomolecular Chemistry Division, Council of Scientific and Industrial Research
Edição: Volume 88, Nº 5 (2018)
Páginas: 1020-1024
Seção: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222212
DOI: https://doi.org/10.1134/S1070363218050304
ID: 222212

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Resumo

A series of 1,2,4-oxadiazole linked imidazothiadiazole derivatives 11a–11j have been synthesized. All derivatives were evaluated for anticancer activity against three human cancer cell lines (A375, MCF-7, and ACHN) and demonstrated activity comparable with that of doxorubicin. Three compounds 11b, 11c, and 11j exhibited higher anticancer activity than the positive control. The range of IC₅₀ for the compounds 11b, 11c, and 11j is determined to be from 0.11 to 2.98 μM.