Synthesis of Pentaerythritol-Based Branching Reagents for Modification of Proteins and Nucleic Acids by [2+3] Dipolar Cycloaddition Reaction
- 作者: Martynenko-Makaev Y.1, Udodova V.1, Sharko O.1, Shmanai V.1
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隶属关系:
- Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
- 期: 卷 88, 编号 3 (2018)
- 页面: 452-461
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222052
- DOI: https://doi.org/10.1134/S1070363218030118
- ID: 222052
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详细
Alkylation of pentaerythritol symmetrically substituted with propylene glycol with propargyl bromide afforded compounds containing two or three alkyne moieties. Amidophosphite reagents and solid supports were prepared for the introduction of two and three acetylene fragments into oligonucleotides at the 3'- and 5'-positions and inside the chain under conditions of automated solid-phase oligonucleotide synthesis. Based on the trialkynyl derivative, an N-hydroxysuccinimide ester was obtained which can be used to modify biomolecules attacking the amino group. Conjugates obtained can be used for multiple modifications by [3+2] dipolar cycloaddition reaction.
作者简介
Yu. Martynenko-Makaev
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
编辑信件的主要联系方式.
Email: yrmart@gmail.com
白俄罗斯, ul. Surganova 13, Minsk, 220072
V. Udodova
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Email: yrmart@gmail.com
白俄罗斯, ul. Surganova 13, Minsk, 220072
O. Sharko
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Email: yrmart@gmail.com
白俄罗斯, ul. Surganova 13, Minsk, 220072
V. Shmanai
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Email: yrmart@gmail.com
白俄罗斯, ul. Surganova 13, Minsk, 220072