Cyclic Amidoalkylation of Hydrophosphorylic Compounds. Synthesis of Proline Analogs


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A method for the synthesis of N-Cbz-protected phosphorylic analogs of proline by cyclic amidoalkylation of various hydrophosphorylic compounds was developed. Combination of amide and carbonyl fragments in the 4-N-Cbz-aminobutyraldehyde molecule allows to realize the three-center two-component amide version of the Kabachnik–Fields reaction.

作者简介

A. Vinyukov

Institute of Physiologically Active Substances

Email: rvalery@dio.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

M. Dmitriev

Institute of Physiologically Active Substances

Email: rvalery@dio.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

A. Yarkevich

Institute of Physiologically Active Substances

Email: rvalery@dio.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

V. Ragulin

Institute of Physiologically Active Substances

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Email: rvalery@dio.ru
俄罗斯联邦, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432


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