Synthesis and antiviral activity of 1,2,3-triazole glycosides based substituted pyridine via click cycloaddition
- 作者: El-Sayed W.1, Khalaf H.1, Mohamed S.2, Hussien H.1, Kutkat O.3, Amr A.4,5
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隶属关系:
- Photochemistry Department
- Applied Organic Chemistry Department
- Environmental Research Division
- Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy
- Chemical Industry Division, Applied Organic Chemistry Department
- 期: 卷 87, 编号 10 (2017)
- 页面: 2444-2453
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221487
- DOI: https://doi.org/10.1134/S1070363217100279
- ID: 221487
如何引用文章
详细
Novel conjugates of substituted pyridine and carbohydrate moieties linked by 1,2,3-triazoles were synthesized. The propargyl group was introduced by O-propargylation of pyridone derivatives. Attachment of carbohydrate molecules to the substituted pyridine core was performed by Cu-catalyzed cycloaddition of propargyl sugars with azidoethoxypyridine derivative or azido-sugars with substituted (propargyl)oxypyridines which afforded the corresponding 1,2,3-triazoles in high yields. Antiviral activity of synthesized compounds was studied against H5N1 influenza virus and triazolyl glycoside 7 demonstrated high activity in addition to its low toxicity. The effect of attachment of glycosyl triazole moieties to pyridinyl system was studied, in SAR correlation, which has been found to enhance antiviral activity.
作者简介
W. El-Sayed
Photochemistry Department
Email: aeamr1963@yahoo.com
埃及, Dokki, Cairo, 12622
H. Khalaf
Photochemistry Department
Email: aeamr1963@yahoo.com
埃及, Dokki, Cairo, 12622
S. Mohamed
Applied Organic Chemistry Department
Email: aeamr1963@yahoo.com
埃及, Dokki, Cairo, 12622
H. Hussien
Photochemistry Department
Email: aeamr1963@yahoo.com
埃及, Dokki, Cairo, 12622
O. Kutkat
Environmental Research Division
Email: aeamr1963@yahoo.com
埃及, Dokki, Cairo, 12622
A. Amr
Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Chemical Industry Division, Applied Organic Chemistry Department
编辑信件的主要联系方式.
Email: aeamr1963@yahoo.com
沙特阿拉伯, Riyadh, 11451; Dokki, Cairo, 12622