Synthesis, antibacterial and antitubercular activity of novel Schiff bases of 2-(1-benzofuran-2-yl)quinoline-4-carboxylic acid derivatives
- 作者: Bodke Y.1, Shankerrao S.1, Kenchappa R.1, Telkar S.2
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隶属关系:
- Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
- Department of Post-Graduate Studies and Research in Biotechnology and Bioinformatics, Jnana Sahyadri
- 期: 卷 87, 编号 8 (2017)
- 页面: 1843-1849
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221130
- DOI: https://doi.org/10.1134/S1070363217080321
- ID: 221130
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详细
Novel Schiff bases of 2-(1-benzofuran-2-yl)quinoline-4-carboxylic acid derivatives 5a–5e were synthesized by the reaction of 2-(1-benzofuran-2-yl)quinoline-4-carbohydrazide 3 with substituted aromatic aldehydes 4a–4e in presence of catalytic amount of acetic acid. Reaction of methyl 2-(1-benzofuran-2-yl)-quinoline-4-carboxylate 2 with hydrazine hydrate upon refluxing in ethanol for 4 h gave the key intermediate, hydrazide compound 3. All newly synthesized compounds were characterized by IR, NMR and Mass spectra and screened for antibacterial and antitubercular activity. Among the tested compounds carbohydrazide 3 and the compounds 5a and 5e exhibited high activity against S. aureus and E. faecalis respectively with MIC 0.064 mg/mL. Compound 5e demonstrated significant activity against S. aureus and E. faecalis with MIC 0.064 mg/mL. The antibacterial tests revealed hydrazide derivative 3 sensitivity at 25 μg/mL, showing high activity among the synthesized compounds.
作者简介
Y. Bodke
Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
编辑信件的主要联系方式.
Email: ydbodke@gmail.com
印度, Shivamogga, Karnataka, 577451
S. Shankerrao
Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
Email: ydbodke@gmail.com
印度, Shivamogga, Karnataka, 577451
R. Kenchappa
Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
Email: ydbodke@gmail.com
印度, Shivamogga, Karnataka, 577451
S. Telkar
Department of Post-Graduate Studies and Research in Biotechnology and Bioinformatics, Jnana Sahyadri
Email: ydbodke@gmail.com
印度, Shankaraghatta, Karnataka, 577451