Synthesis and properties of 2-(furan-2-yl)thiazolo[5,4-f]quinoline
- 作者: El’chaninov M.1, Aleksandrov А.1
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隶属关系:
- Platov South-Russian State Polytechnic University
- 期: 卷 87, 编号 8 (2017)
- 页面: 1711-1715
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220967
- DOI: https://doi.org/10.1134/S1070363217080126
- ID: 220967
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详细
N-(Quinolin-6-yl)furan-2-carboxamide was prepared by the coupling of quinoline-6-amine with furan-2-carbonyl chloride in propan-2-ol. Treatment of the product with excess Р2S5 in anhydrous pyridine gave N-(quinolin-6-yl)furan-2-carbothioamide which was oxidized with potassium ferricyanide in an alkaline medium by the Jakobson procedure to obtain 2-(furan-2-yl)thiazolo[5,4-f]quinoline. The latter was subjected to electrophilic substitution reactions (nitration, bromination, formylation, and acylation), as well as characteristic nucleophilic substitution involving the quinoline ring and quaternization with methyl iodide in benzene.
作者简介
M. El’chaninov
Platov South-Russian State Polytechnic University
编辑信件的主要联系方式.
Email: elchaninov-43@mail.ru
俄罗斯联邦, pr. Prosveshcheniya 132, Novocherkassk, 346428
А. Aleksandrov
Platov South-Russian State Polytechnic University
Email: elchaninov-43@mail.ru
俄罗斯联邦, pr. Prosveshcheniya 132, Novocherkassk, 346428
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