Triazole metal based complexes as antibacterial/antifungal agents
- 作者: Sumrra S.1, Suleman A.1, Chohan Z.1, Zafar M.1, Raza M.1, Iqbal T.2
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隶属关系:
- Department of Chemistry
- HEJ Research Institute of Chemistry
- 期: 卷 87, 编号 6 (2017)
- 页面: 1281-1287
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/220356
- DOI: https://doi.org/10.1134/S107036321706024X
- ID: 220356
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详细
Biologically active triazole derived Schiff bases, 2-methoxy-6-[(Z)-(1H-1,2,4-triazol-3-ylimino) methyl]phenol (L1) and 4-[(Z)-(1H-1,2,4-triazol-3-ylimino)methyl]benzene-1,3-diol (L2) were prepared by condensing 3-amino-1,2,4-triazole with 2-hydroxy-3-methoxybenzaldehyde and 2,4-dihydroxybenzaldehyde in the 1 : 1 molar ratio. Structures of the synthesized ligands were characterized by IR, NMR and Mass spectral data. The ligands were complexed with the ions of V, Cr, Mn, Fe, Co, Ni, Cu, and Zn to form the complexes M : L in the 1 : 2 molar ratio. The synthesized Schiff bases potentially behaved as tridentate ligands and coordinated to metal ions via azomethine-N, triazole-N, and benzaldehyde-O. Structure elucidation of complexes involved IR, UV-Vis, MS, and molar conductance data. These compounds were tested for antibacterial activity against Halomonas halophila, Chromohalobacter israelensis, Chromohalobacter salexigens, Staphylococcus aureus, Halomonas salina, and Neisseria gonorrhoeae bacterial stains. Antifungal activity of the synthesized compounds was studied by using different fungal stains like Trichophyton Longifusus, Candida Albicans, Aspergillus Flavus, Microsporum Canis, Fusarium, Solani, and Candida Glabrata. All synthesized compounds displayed high antimicrobial activity against one or more strains.
作者简介
S. Sumrra
Department of Chemistry
编辑信件的主要联系方式.
Email: sajjadchemist@uog.edu.pk
巴基斯坦, Gujrat, 50700
A. Suleman
Department of Chemistry
Email: sajjadchemist@uog.edu.pk
巴基斯坦, Gujrat, 50700
Z. Chohan
Department of Chemistry
Email: sajjadchemist@uog.edu.pk
巴基斯坦, Sargodha
M. Zafar
Department of Chemistry
Email: sajjadchemist@uog.edu.pk
巴基斯坦, Islamabad, 45320
M. Raza
Department of Chemistry
Email: sajjadchemist@uog.edu.pk
巴基斯坦, Gujrat, 50700
T. Iqbal
HEJ Research Institute of Chemistry
Email: sajjadchemist@uog.edu.pk
巴基斯坦, Karachi