Triazole metal based complexes as antibacterial/antifungal agents

Abstract

Biologically active triazole derived Schiff bases, 2-methoxy-6-[(Z)-(1H-1,2,4-triazol-3-ylimino) methyl]phenol (L₁) and 4-[(Z)-(1H-1,2,4-triazol-3-ylimino)methyl]benzene-1,3-diol (L₂) were prepared by condensing 3-amino-1,2,4-triazole with 2-hydroxy-3-methoxybenzaldehyde and 2,4-dihydroxybenzaldehyde in the 1 : 1 molar ratio. Structures of the synthesized ligands were characterized by IR, NMR and Mass spectral data. The ligands were complexed with the ions of V, Cr, Mn, Fe, Co, Ni, Cu, and Zn to form the complexes M : L in the 1 : 2 molar ratio. The synthesized Schiff bases potentially behaved as tridentate ligands and coordinated to metal ions via azomethine-N, triazole-N, and benzaldehyde-O. Structure elucidation of complexes involved IR, UV-Vis, MS, and molar conductance data. These compounds were tested for antibacterial activity against Halomonas halophila, Chromohalobacter israelensis, Chromohalobacter salexigens, Staphylococcus aureus, Halomonas salina, and Neisseria gonorrhoeae bacterial stains. Antifungal activity of the synthesized compounds was studied by using different fungal stains like Trichophyton Longifusus, Candida Albicans, Aspergillus Flavus, Microsporum Canis, Fusarium, Solani, and Candida Glabrata. All synthesized compounds displayed high antimicrobial activity against one or more strains.