Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2 H -indazole Derivatives

V. L. Gein; A. N. Yankin; N. V. Nosova; E. B. Levandovskaya; V. V. Novikova; I. P. Rudakova

doi:10.1134/S1070363219060112

Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives

Авторы: Gein V.¹, Yankin A.², Nosova N.¹, Levandovskaya E.¹, Novikova V.¹, Rudakova I.¹
Учреждения:
1. Perm State Pharmaceutical Academy
2. St. Petersburg State University
Выпуск: Том 89, № 6 (2019)
Страницы: 1169-1176
Раздел: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222939
DOI: https://doi.org/10.1134/S1070363219060112
ID: 222939

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Аннотация

Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N¹,N³,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities