Synthesis, Characterization, and Antimicrobial Assessment of Some Computationally Bioactive 1,2-Oxazole Derivatives
- Авторы: Arshad M.1
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Учреждения:
- Department of Basic Sciences, College of Medicine Al-Dawadmi
- Выпуск: Том 88, № 9 (2018)
- Страницы: 1886-1891
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222422
- DOI: https://doi.org/10.1134/S1070363218090207
- ID: 222422
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Аннотация
1,2-Oxazole derivatives 1–6 were designed and evaluated computationally to calculate the physicochemical properties and the bioactivity score by Mol-inspiration, and were determined to possess very good activity score. 1,2-Oxazoles were then synthesized, characterized by FT-IR, 1H NMR and mass spectroscopy, and tested for antibacterial activity against the pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Proteus mirabilis). The antibacterial therapeutic effect strongly supported the prior computational results. Four synthesized compounds 2, 4–6 demonstrated antibacterial potential higher than the standard drug Ciprofloxacin.
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Об авторах
M. Arshad
Department of Basic Sciences, College of Medicine Al-Dawadmi
Автор, ответственный за переписку.
Email: m.arshad@su.edu.sa
Саудовская Аравия, Shaqra