Synthesis, Characterization, and Antimicrobial Assessment of Some Computationally Bioactive 1,2-Oxazole Derivatives
- Authors: Arshad M.1
-
Affiliations:
- Department of Basic Sciences, College of Medicine Al-Dawadmi
- Issue: Vol 88, No 9 (2018)
- Pages: 1886-1891
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222422
- DOI: https://doi.org/10.1134/S1070363218090207
- ID: 222422
Cite item
Abstract
1,2-Oxazole derivatives 1–6 were designed and evaluated computationally to calculate the physicochemical properties and the bioactivity score by Mol-inspiration, and were determined to possess very good activity score. 1,2-Oxazoles were then synthesized, characterized by FT-IR, 1H NMR and mass spectroscopy, and tested for antibacterial activity against the pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Proteus mirabilis). The antibacterial therapeutic effect strongly supported the prior computational results. Four synthesized compounds 2, 4–6 demonstrated antibacterial potential higher than the standard drug Ciprofloxacin.
About the authors
M. Arshad
Department of Basic Sciences, College of Medicine Al-Dawadmi
Author for correspondence.
Email: m.arshad@su.edu.sa
Saudi Arabia, Shaqra