Synthesis of pyrano isoxazoline/isoxazole annulated coumarins via intramolecular nitrile oxide cycloaddition and their cytotoxicity
- Авторы: Krishna C.1, Bhargavi M.2, Rao Y.1, Krupadanam G.1
-
Учреждения:
- Department of Chemistry, Faculty of Science
- Department of Pharmacy, Faculty of Technology
- Выпуск: Том 87, № 8 (2017)
- Страницы: 1857-1863
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221154
- DOI: https://doi.org/10.1134/S1070363217080345
- ID: 221154
Цитировать
Аннотация
An efficient and straight forward procedure for the syntheses of isoxazoline/isoxazole fused coumarin analogues 7a–7g and 8a–8g from the corresponding 7-O-allyloxy coumarin oximes 5a–5g and 7-O-propargyloxy coumarin oximes 6a–6g is presented. High yields and simple experimental procedures are important features of this methodology. This method is useful for the construction of many biologically active fused heterocycles. The structures of synthesized compounds are established on the basis of IR, NMR, and MS data. The products were tested for in vitro cytotoxic activity against three human cancer cell lines. All tested compounds demonstrated high cytotoxic activity.
Ключевые слова
Об авторах
C. Krishna
Department of Chemistry, Faculty of Science
Автор, ответственный за переписку.
Email: challakrishna76@gmail.com
Индия, Hyderabad, 500007
M. Bhargavi
Department of Pharmacy, Faculty of Technology
Email: challakrishna76@gmail.com
Индия, Hyderabad, 500007
Y. Rao
Department of Chemistry, Faculty of Science
Email: challakrishna76@gmail.com
Индия, Hyderabad, 500007
G. Krupadanam
Department of Chemistry, Faculty of Science
Email: challakrishna76@gmail.com
Индия, Hyderabad, 500007