Synthesis, biological evaluation, and molecular docking studies of novel 1,2,3-triazole derivatives as potent anti-inflammatory agents
- Авторы: Kishore Kumar A.1, Sunitha V.1, Shankar B.1, Ramesh M.1, Murali Krishna T.2, Jalapathi P.1
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Учреждения:
- Department of Chemistry, University College of Science
- Department of Biotechnology, Chaitanya Postgraduate College (Autonomous)
- Выпуск: Том 86, № 5 (2016)
- Страницы: 1154-1162
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215084
- DOI: https://doi.org/10.1134/S1070363216050297
- ID: 215084
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Аннотация
In the present study, a novel series of 1,2,3-triazole derivatives have been synthesized using click chemistry approach. The structures were confirmed by spectroscopic methods. The products were screened for their in vivo anti-inflammatory activity. The tested compounds 6a, 6f, 6g, 6i, 6j, 6n, and 6p, demonstrated potent anti-inflammatory activity compared to the reference drug ibuprofen. Molecular docking studies of these 1,2,3-triazole derivatives into the active site of human cyclooxygenase-2 (COX-2) (PDB code 4PH9) demonstrated good affinity for the enzyme and suggested binding properties similar to ibuprofen.
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Об авторах
A. Kishore Kumar
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
Индия, Saifabad, Telangana, Hyderabad, 500004
V. Sunitha
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
Индия, Saifabad, Telangana, Hyderabad, 500004
B. Shankar
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
Индия, Saifabad, Telangana, Hyderabad, 500004
M. Ramesh
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
Индия, Saifabad, Telangana, Hyderabad, 500004
T. Murali Krishna
Department of Biotechnology, Chaitanya Postgraduate College (Autonomous)
Email: pochampalli.ou.chemi@gmail.com
Индия, Kishanpura, Hanamkonda, Telangana, Warangal, 506001
P. Jalapathi
Department of Chemistry, University College of Science
Автор, ответственный за переписку.
Email: pochampalli.ou.chemi@gmail.com
Индия, Saifabad, Telangana, Hyderabad, 500004
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