Synthesis, biological evaluation, and molecular docking studies of novel 1,2,3-triazole derivatives as potent anti-inflammatory agents
- Authors: Kishore Kumar A.1, Sunitha V.1, Shankar B.1, Ramesh M.1, Murali Krishna T.2, Jalapathi P.1
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Affiliations:
- Department of Chemistry, University College of Science
- Department of Biotechnology, Chaitanya Postgraduate College (Autonomous)
- Issue: Vol 86, No 5 (2016)
- Pages: 1154-1162
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215084
- DOI: https://doi.org/10.1134/S1070363216050297
- ID: 215084
Cite item
Abstract
In the present study, a novel series of 1,2,3-triazole derivatives have been synthesized using click chemistry approach. The structures were confirmed by spectroscopic methods. The products were screened for their in vivo anti-inflammatory activity. The tested compounds 6a, 6f, 6g, 6i, 6j, 6n, and 6p, demonstrated potent anti-inflammatory activity compared to the reference drug ibuprofen. Molecular docking studies of these 1,2,3-triazole derivatives into the active site of human cyclooxygenase-2 (COX-2) (PDB code 4PH9) demonstrated good affinity for the enzyme and suggested binding properties similar to ibuprofen.
Keywords
About the authors
A. Kishore Kumar
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Telangana, Hyderabad, 500004
V. Sunitha
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Telangana, Hyderabad, 500004
B. Shankar
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Telangana, Hyderabad, 500004
M. Ramesh
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Telangana, Hyderabad, 500004
T. Murali Krishna
Department of Biotechnology, Chaitanya Postgraduate College (Autonomous)
Email: pochampalli.ou.chemi@gmail.com
India, Kishanpura, Hanamkonda, Telangana, Warangal, 506001
P. Jalapathi
Department of Chemistry, University College of Science
Author for correspondence.
Email: pochampalli.ou.chemi@gmail.com
India, Saifabad, Telangana, Hyderabad, 500004