Kumada cross coupling reaction based synthesis, antimicrobial and computational studies of 6-aryl-2-phenyl-3-methylquinazolin-4(3H)-ones
- Авторы: Shankaraiah P.1, Veeresham S.1, Bhavani A.1
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Учреждения:
- Department of Chemistry, University College of Science, Saifabad
- Выпуск: Том 86, № 2 (2016)
- Страницы: 368-375
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213914
- DOI: https://doi.org/10.1134/S1070363216020286
- ID: 213914
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Аннотация
Nickel catalyzed Kumada cross coupling reaction, a novel synthetic method for the synthesis of 6-aryl-2-phenyl-3-methylquinazolin-4(3H)-ones (6a–6i), was carried out by condensing 6-iodo-2-phenyl-3-methyl-quinazolin-4(3H)-one (4) with various 6-aryl/heteroaryl Grignard reagents. Molecular properties of compounds 4 and 6a–6i were studied using semiempirical PM3 computational method. The optimized geometry of the product 6 indicated that the aryl group at the position 6 was not coplanar with respect to either quinazolinone ring or phenyl group at 2 position. Compounds 6a–6i were screened for their activity against bacteria and fungi.
Об авторах
P. Shankaraiah
Department of Chemistry, University College of Science, Saifabad
Email: akdbhavaniou@yahoo.com
Индия, Hyderabad, 500004
S. Veeresham
Department of Chemistry, University College of Science, Saifabad
Email: akdbhavaniou@yahoo.com
Индия, Hyderabad, 500004
A. Bhavani
Department of Chemistry, University College of Science, Saifabad
Автор, ответственный за переписку.
Email: akdbhavaniou@yahoo.com
Индия, Hyderabad, 500004