Kumada cross coupling reaction based synthesis, antimicrobial and computational studies of 6-aryl-2-phenyl-3-methylquinazolin-4(3H)-ones
- Authors: Shankaraiah P.1, Veeresham S.1, Bhavani A.K.1
-
Affiliations:
- Department of Chemistry, University College of Science, Saifabad
- Issue: Vol 86, No 2 (2016)
- Pages: 368-375
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213914
- DOI: https://doi.org/10.1134/S1070363216020286
- ID: 213914
Cite item
Abstract
Nickel catalyzed Kumada cross coupling reaction, a novel synthetic method for the synthesis of 6-aryl-2-phenyl-3-methylquinazolin-4(3H)-ones (6a–6i), was carried out by condensing 6-iodo-2-phenyl-3-methyl-quinazolin-4(3H)-one (4) with various 6-aryl/heteroaryl Grignard reagents. Molecular properties of compounds 4 and 6a–6i were studied using semiempirical PM3 computational method. The optimized geometry of the product 6 indicated that the aryl group at the position 6 was not coplanar with respect to either quinazolinone ring or phenyl group at 2 position. Compounds 6a–6i were screened for their activity against bacteria and fungi.
About the authors
P. Shankaraiah
Department of Chemistry, University College of Science, Saifabad
Email: akdbhavaniou@yahoo.com
India, Hyderabad, 500004
S. Veeresham
Department of Chemistry, University College of Science, Saifabad
Email: akdbhavaniou@yahoo.com
India, Hyderabad, 500004
A. K. D. Bhavani
Department of Chemistry, University College of Science, Saifabad
Author for correspondence.
Email: akdbhavaniou@yahoo.com
India, Hyderabad, 500004