Synthesis, Type II Diabetes Inhibitory Activity, and Antimicrobial Tests of Benzothiazole Derivatives Bridged with Indenedione by Methylenehydrazone
- Autores: Mor S.1, Sindhu S.1, Khatri M.1, Singh N.2, Vasudeva N.3, Panihar N.3
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Afiliações:
- Department of Chemistry
- Department of Bio and Nanotechnology
- Department of Pharmaceutical Sciences
- Edição: Volume 89, Nº 9 (2019)
- Páginas: 1867-1873
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223085
- DOI: https://doi.org/10.1134/S1070363219090226
- ID: 223085
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Resumo
Benzothiazolyl hydrazones are synthesized and tested as hypoglycemic and antimicrobial agents. Condensation of 2-acyl-(1H)-indene-1,3(2H)-diones with 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles gives the corresponding hydrazones in high yields. Preliminary biological assay of the products reveals significant antidiabetic and antimicrobial activities. The α-amylase and α-glucosidase inhibition assay is used for determination of Type II diabetes inhibitory activity.
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Sobre autores
S. Mor
Department of Chemistry
Autor responsável pela correspondência
Email: satbir_mor@yahoo.co.in
Índia, Hisar, Haryana, 125001
S. Sindhu
Department of Chemistry
Email: satbir_mor@yahoo.co.in
Índia, Hisar, Haryana, 125001
M. Khatri
Department of Chemistry
Email: satbir_mor@yahoo.co.in
Índia, Hisar, Haryana, 125001
N. Singh
Department of Bio and Nanotechnology
Email: satbir_mor@yahoo.co.in
Índia, Hisar, Haryana, 125001
N. Vasudeva
Department of Pharmaceutical Sciences
Email: satbir_mor@yahoo.co.in
Índia, Hisar, Haryana, 125001
N. Panihar
Department of Pharmaceutical Sciences
Email: satbir_mor@yahoo.co.in
Índia, Hisar, Haryana, 125001