Synthesis, Type II Diabetes Inhibitory Activity, and Antimicrobial Tests of Benzothiazole Derivatives Bridged with Indenedione by Methylenehydrazone

S. Mor; S. Sindhu; M. Khatri; N. Singh; N. Vasudeva; N. Panihar

doi:10.1134/S1070363219090226

Synthesis, Type II Diabetes Inhibitory Activity, and Antimicrobial Tests of Benzothiazole Derivatives Bridged with Indenedione by Methylenehydrazone

Авторлар: Mor S.¹, Sindhu S.¹, Khatri M.¹, Singh N.², Vasudeva N.³, Panihar N.³
Мекемелер:
1. Department of Chemistry
2. Department of Bio and Nanotechnology
3. Department of Pharmaceutical Sciences
Шығарылым: Том 89, № 9 (2019)
Беттер: 1867-1873
Бөлім: Article
URL: https://journals.rcsi.science/1070-3632/article/view/223085
DOI: https://doi.org/10.1134/S1070363219090226
ID: 223085

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Аннотация

Benzothiazolyl hydrazones are synthesized and tested as hypoglycemic and antimicrobial agents. Condensation of 2-acyl-(1H)-indene-1,3(2H)-diones with 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles gives the corresponding hydrazones in high yields. Preliminary biological assay of the products reveals significant antidiabetic and antimicrobial activities. The α-amylase and α-glucosidase inhibition assay is used for determination of Type II diabetes inhibitory activity.