Synthesis and Fungicidal Activity of Bis-1,5,3-dithiazepanes and Crown-Like Macroheterocycles

Resumo

An efficient method was developed for the synthesis of bis-1,5,3-dithiazepanes and crown-like N-cycloalkyl-1,11-dioxa-4,8-dithia-6-azacyclotridecanes by heterocyclization of cyclohexane-substituted diamines and carbocyclic primary amines with N, N, N¹, N¹-tetramethylmethanediamine and aliphatic α,ω-dithiols using SmCl₃-6H₂O as a catalyst. Fungicidal activity of 1,3-bis[(1,5,3-dithiazepan-3-yl)methyl]cyclohexane and 6-cyclopropyl-1,11-dioxa-4,8-dithia-6-azacyclotridecane in relation to Rhizoctonia solani and Candida albicans strains was revealed.