Enviar artigo por via de e-mail Novel Pyran and Polyhydroquinoline Derivatives: Inhibiting Human Osteosarcoma Activity
- Autores: Fan X.1, Shen P.1, Zhou X.1
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Afiliações:
- Department of Orthopaedics
- Edição: Volume 88, Nº 6 (2018)
- Páginas: 1247-1251
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222271
- DOI: https://doi.org/10.1134/S1070363218060336
- ID: 222271
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Resumo
A series of pyran 1–6 and polyhydroquinoline derivatives 7–9 are synthesized targeting anticancer agents for clinical trials. Their structures are characterized by IR, 1H NMR, and HRMS spectra, and single crystal X-ray crystallography. Their anticancer activity against four human osteosarcoma cells (Saos-2, MG-63, 143B, and U2-OS) is evaluated in vitro using the MTT assay. The compounds 7–9 demonstrate high anticancer activity against the four cancer cells.
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Sobre autores
X.-X. Fan
Department of Orthopaedics
Email: xinhua_zhou666@yeah.net
República Popular da China, Huzhou, Zhejiang, 313003
P. Shen
Department of Orthopaedics
Email: xinhua_zhou666@yeah.net
República Popular da China, Huzhou, Zhejiang, 313003
X.-H. Zhou
Department of Orthopaedics
Autor responsável pela correspondência
Email: xinhua_zhou666@yeah.net
República Popular da China, Huzhou, Zhejiang, 313003
